New USC study reveals how DNA loops silence gene activity
The blueprint for human life lies within the DNA in the nucleus of each of our cells. In human cells, around six and a half feet of this genetic material must be condensed to fit inside the nucleus. DNA condensation is not random.
news-medical.net/news/20240116/New-USC-study-reveals-how-DNA-loops-silence-gene-activity.aspx
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Pioneering Genomic Progress: An Interview with Rami Mehio, Illumina's Software and Informatics Expert
In this interview, Rami Mehio, head of software and informatics at Illumina, shares his experiences and contributions to major genomic projects like the UK Biobank's whole genome sequencing. He discusses the challenges and innovations in genomic data analysis, highlighting Illumina's role in advancing genetic research and precision medicine.
news-medical.net/news/20240115/Pioneering-Genomic-Progress-An-Interview-with-Rami-Mehio-Illuminas-Software-and-Informatics-Expert.aspx
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Scientists develop noninvasive way to monitor gene expression dynamics in the brain
Researchers introduced a non-invasive, sensitive method for monitoring gene expression in the brain using engineered reporters called released markers of activity, which can exit the brain into the blood for easy detection.
news-medical.net/news/20240112/Scientists-develop-noninvasive-way-to-monitor-gene-expression-dynamics-in-the-brain.aspx
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Revolutionary blood test monitors gene expression dynamics in the brain
The brain is the most protected organ in the body, sheathed in a complex and nearly impenetrable barrier of specialized blood vessels.
news-medical.net/news/20240111/Revolutionary-blood-test-monitors-gene-expression-dynamics-in-the-brain.aspx
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New algorithm proves to be a powerful tool for detection and identification of novel bacterial organisms
Researchers developed the NOVA algorithm to systematically analyze bacterial isolates unidentified using traditional methods such as matrix-assisted laser desorption ionization-time of flight mass spectrometry and partial 16S rRNA gene sequencing using whole genome sequencing.
news-medical.net/news/20240110/New-algorithm-proves-to-be-a-powerful-tool-for-detection-and-identification-of-novel-bacterial-organisms.aspx
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"TimeMachine" algorithm revolutionizes circadian rhythm analysis with single blood sample
"TimeMachine," an algorithm developed by U.S. researchers, accurately predicts circadian phase from a single blood sample using gene expression, offering a novel, efficient approach to understanding circadian rhythms and their impact on health.
news-medical.net/news/20240109/TimeMachine-algorithm-revolutionizes-circadian-rhythm-analysis-with-single-blood-sample.aspx
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Breakthrough in gene editing: Enhanced virus-like particles promise new era in genetic disease treatment
Researchers developed an advanced prime editor-engineered virus-like particle (PE-eVLP) system, significantly enhancing gene editing efficiency in human cells and showing potential for treating genetic diseases.
news-medical.net/news/20240109/Breakthrough-in-gene-editing-Enhanced-virus-like-particles-promise-new-era-in-genetic-disease-treatment.aspx
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Disease-causing bacteria use molecular "barcode" to distinguish between beneficial and toxic molecules
Researchers at McMaster University have discovered a molecular "barcode" system used by disease-causing bacteria to distinguish between beneficial and toxic molecules.
news-medical.net/news/20240108/Disease-causing-bacteria-use-molecular-barcode-to-distinguish-between-beneficial-and-toxic-molecules.aspx
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Sesame protein-derived peptides show promise in fighting E. coli and S. aureus
A study in "Nutrients" reveals that sesame protein-derived peptides, Ala-Gly-Gly-Val-Pro-Arg and Ser-Thr-Ile-Arg, show effective antibacterial activity against Escherichia coli and Staphylococcus aureus.
news-medical.net/news/20240107/Sesame-protein-derived-peptides-show-promise-in-fighting-E-coli-and-S-aureus.aspx
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Metabolically armored CAR-T cells demonstrate lasting efficacy against solid tumors
At EPFL's School of Engineering, Professor Li Tang's Laboratory of Biomaterials for Immunoengineering has made significant strides in cancer treatment research.
news-medical.net/news/20240104/Metabolically-armored-CAR-T-cells-demonstrate-lasting-efficacy-against-solid-tumors.aspx
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Unmasking the persistent threats of long-COVID's pulmonary sequelae
A collaborative study led by Dr. Estefanía Nova-Lamperti of the Universidad de Concepción, Dr. Gonzalo Labarca of Harvard University, and Mauricio Hernández, of MELISA Institute, and which included the participation of researchers from leading academic institutions, sought to identify the sequelae associated with long-term pulmonary dysfunction (L-PDD) in patients with COVID-19.
news-medical.net/news/20240104/Unmasking-the-persistent-threats-of-long-COVIDs-pulmonary-sequelae.aspx
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Are pan-coronavirus vaccines an achievable goal in providing broad protection against human coronaviruses?
The current achievements in the development of a pan-coronavirus vaccine.
news-medical.net/news/20240103/Are-pan-coronavirus-vaccines-an-achievable-goal-in-providing-broad-protection-against-human-coronaviruses.aspx
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📑 In silico Methods for Identification of Potential Therapeutic Targets
📘 Journal: Cancers (I.F.=4.8)
🗓 Publish year: 2022
📎 Study the paper
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#review #therapeutic
Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors
Insilico Medicine ("Insilico"), a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.
news-medical.net/news/20231228/Insilico-Medicine-develops-new-AI-generated-FGFR23-inhibitor-for-tissue-agnostic-solid-tumors.aspx
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Monkey stem cells made easy: New method unveils xeno-free, efficient culture system
Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.
news-medical.net/news/20231222/Monkey-stem-cells-made-easy-New-method-unveils-xeno-free-efficient-culture-system.aspx
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Combining health data with whole genome sequence data in cancer patients can help doctors provide more tailored care
Researchers evaluated the impact of integrating whole-genome sequencing data with clinical outcomes across 13,880 tumors from 33 cancer types, assessing precision care potentials within the UK NHS through the 100,000 Genomes Cancer Programme.
news-medical.net/news/20240116/Combining-health-data-with-whole-genome-sequence-data-in-cancer-patients-can-help-doctors-provide-more-tailored-care.aspx
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When mass spectrometry redefines the pharma industry
In this new episode of omg OMx, Kate Stumpo speaks to Bruker's Mike Greig about the incredible
potential of mass spectrometry in pharma.
news-medical.net/news/20240112/When-mass-spectrometry-redefines-the-pharma-industry.aspx
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New molecule targets key protein in autoimmune diseases
Scientists from Scripps Research have developed a small molecule that blocks the activity of a protein linked to autoimmune diseases, including systemic lupus erythematosus (SLE) and Crohn's disease.
news-medical.net/news/20240111/New-molecule-targets-key-protein-in-autoimmune-diseases.aspx
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BCG vaccine's impact on innate immunity explained at cellular level
Bacillus Calmette-Guérin (BCG) is one of the world’s oldest and most widely used vaccines. It was developed in the early 20th century to provide protection from tuberculosis.
news-medical.net/news/20240109/BCG-vaccines-impact-on-innate-immunity-explained-at-cellular-level.aspx
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Using machine learning to predict disease progression in multiple sclerosis
A combination of only 11 proteins can predict long-term disability outcomes in multiple sclerosis (MS) for different individuals.
news-medical.net/news/20240109/Using-machine-learning-to-predict-disease-progression-in-multiple-sclerosis.aspx
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New approach to Parkinson's treatment focuses on stopping toxic protein production
Like the Greek mythological beast with a snake's tail and two ferocious heads, a potential Parkinson's medicine created in the lab of chemist Matthew Disney, Ph.D., is also a type of chimera bearing two heads.
news-medical.net/news/20240109/New-approach-to-Parkinsons-treatment-focuses-on-stopping-toxic-protein-production.aspx
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The equity imperative: A roundtable on transforming healthcare
In the Roundtable titled "A Glimpse at How Stakeholders Are Working Towards Achieving Health Equity," published in the peer-reviewed journal Health Equity, two expert panel discussions examine efforts to achieve maternal health equity and changes that health systems can make to operationalize health equity.
news-medical.net/news/20240109/The-equity-imperative-A-roundtable-on-transforming-healthcare.aspx
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Engineered virus-like particles power up gene editing, correcting blindness in mice
Prime editing, a versatile form of gene editing that can correct most known disease-causing genetic mutations, now has a new vehicle to deliver its machinery into cells in living animals.
news-medical.net/news/20240108/Engineered-virus-like-particles-power-up-gene-editing-correcting-blindness-in-mice.aspx
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Discovery on housekeeping genetic elements reveals a novel avenue in cancer therapy
Technological advancements have enabled scientists to comprehensively explore genetic control elements, unraveling the complexities of gene activation mechanisms in our genetic code.
news-medical.net/news/20240105/Discovery-on-housekeeping-genetic-elements-reveals-a-novel-avenue-in-cancer-therapy.aspx
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Revolutionary RNA-based switch offers new control over gene expression in mammalian cells
Researchers developed an RNA-based switch, the pA regulator system, to control gene expression in mammalian cells by modulating synthetic polyA signal cleavage, offering a novel approach for gene therapy applications.
news-medical.net/news/20240104/Revolutionary-RNA-based-switch-offers-new-control-over-gene-expression-in-mammalian-cells.aspx
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Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection
An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice.
news-medical.net/news/20240103/Eastern-equine-encephalitis-virus-study-uncovers-decoy-molecule-that-protects-against-deadly-brain-infection.aspx
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New AI tool spotlights hidden cancers for better diagnosis
A new artificial intelligence tool that interprets medical images with unprecedented clarity does so in a way that could allow time-strapped clinicians to dedicate their attention to critical aspects of disease diagnosis and image interpretation.
news-medical.net/news/20240102/New-AI-tool-spotlights-hidden-cancers-for-better-diagnosis.aspx
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Small molecule-switchable RNA platform enables control of therapeutic protein expression
Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window.
news-medical.net/news/20240102/Small-molecule-switchable-RNA-platform-enables-control-of-therapeutic-protein-expression.aspx
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Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition
The Asian Fund for Cancer Research (AFCR) is pleased to announce that Degron Therapeutics was selected as the winner of the 2023 BRACE Award Venture Competition.
news-medical.net/news/20231227/Degron-Therapeutics-announced-as-winner-of-AFCRs-2023-BRACE-Award-Venture-Competition.aspx
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New tool organizes single-cell data for health discoveries
A new methodology that allows for the categorization and organisation of single-cell data has been launched. It can be used to create a harmonized dataset for the study of human health and disease.
news-medical.net/news/20231221/New-tool-organizes-single-cell-data-for-health-discoveries.aspx
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