Novel drug nitisinone could help reduce malaria spread by killing mosquitoes
In the fight against malaria, controlling the mosquito population is crucial.
news-medical.net/news/20250326/Novel-drug-nitisinone-could-help-reduce-malaria-spread-by-killing-mosquitoes.aspx
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Breakthrough DNA delivery system could revolutionize chronic disease treatment
A breakthrough in safely delivering therapeutic DNA to cells could transform treatment for millions suffering from common chronic diseases like heart disease, diabetes, and cancer.
news-medical.net/news/20250325/Breakthrough-DNA-delivery-system-could-revolutionize-chronic-disease-treatment.aspx
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Researchers trace 73% of US Salmonella cases to chicken and vegetables
Researchers used genome sequencing and machine learning to trace the top food sources behind Salmonella infections in the US. Chicken and vegetables emerged as the primary culprits, together accounting for up to 73% of human cases with known sources.
news-medical.net/news/20250323/Researchers-trace-7325-of-US-Salmonella-cases-to-chicken-and-vegetables.aspx
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250,000 whole genomes sequenced for AGD initiative to advance drug discovery
Nashville Biosciences LLC (NashBio), a leading clinical and genomic data company and wholly owned subsidiary of Vanderbilt University Medical Center, and global DNA sequencing giant Illumina Inc. today announced that 250,000 whole genomes have been sequenced for the Alliance for Genomic Discovery (AGD) initiative.
news-medical.net/news/20250321/250000-whole-genomes-sequenced-for-AGD-initiative-to-advance-drug-discovery.aspx
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Melanoma cells use stealth strategy to survive targeted therapy
Researchers have uncovered a stealth survival strategy that melanoma cells use to evade targeted therapy, offering a promising new approach to improving treatment outcomes.
news-medical.net/news/20250320/Melanoma-cells-use-stealth-strategy-to-survive-targeted-therapy.aspx
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New RNA barcoding method tracks gene transfer in microbial communities
In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive antibiotic resistance and even shape entire ecosystems.
news-medical.net/news/20250319/New-RNA-barcoding-method-tracks-gene-transfer-in-microbial-communities.aspx
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Biomanufacturing platform offers a sustainable alternative to synthesizing peptide-based pharmaceuticals
To tackle the inequity in medication access, a societal issue especially in developing nations, a team of undergraduate student-researchers at the University of Ottawa has developed a new biomanufacturing platform called Phytogene.
news-medical.net/news/20250318/Biomanufacturing-platform-offers-a-sustainable-alternative-to-synthesizing-peptide-based-pharmaceuticals.aspx
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Discovery of new protein could revolutionize cancer drug delivery
A previously unknown protein in a family of bacteria found in soil and the human gut microbiome has been discovered – which could help drug delivery in cancer treatment.
news-medical.net/news/20250317/Discovery-of-new-protein-could-revolutionize-cancer-drug-delivery.aspx
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SolasCure enrols first patient in a next phase II clinical trial to advance Aurase Wound Gel
SOLASCURE Ltd (SolasCure), a biotechnology company developing a novel treatment to transform chronic wound healing, today announced the initiation of a new Phase II clinical trial, CLEANVLU2.
news-medical.net/news/20250317/SolasCure-enrols-first-patient-in-a-next-phase-II-clinical-trial-to-advance-Aurase-Wound-Gel.aspx
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Study shows impact of statins and aspirin on muscle health in smokers
For current and former smokers, statins may reduce the amount of chest muscle loss, while aspirin may contribute to increased chest muscle loss, according to a new study.
news-medical.net/news/20250313/Study-shows-impact-of-statins-and-aspirin-on-muscle-health-in-smokers.aspx
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Platelet-rich plasma may enhance ovarian rejuvenation and improve egg quality in women
A new research paper was published in Aging (Aging-US) on February 18, 2025, Volume 17, Issue 2, titled "Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP)."
news-medical.net/news/20250310/Platelet-rich-plasma-may-enhance-ovarian-rejuvenation-and-improve-egg-quality-in-women.aspx
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Many individuals with Niemann-Pick disease lack neutralizing antibodies against AAV2 or AAV9
A new study in the peer-reviewed journal Human Gene Therapy showed that more than half of individuals with Niemann-Pick disease, type C1 (NPC1) who were tested lacked neutralizing antibodies against either adeno-associated virus (AAV) 2 or AAV9.
news-medical.net/news/20250310/Many-individuals-with-Niemann-Pick-disease-lack-neutralizing-antibodies-against-AAV2-or-AAV9-A.aspx
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Insilico Medicine's AI-driven drug Rentosertib receives official generic name
Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven biotechnology company, recently announced that its breakthrough drug candidate for idiopathic pulmonary fibrosis (IPF) – Rentosertib (formerly known as ISM001-055) – has been granted an official generic name by the United States Adopted Names (USAN) Council.
news-medical.net/news/20250307/Insilico-Medicines-AI-driven-drug-Rentosertib-receives-official-generic-name.aspx
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Researchers discover brain's ability to reorganize sensory maps after loss of touch
A team of researchers from the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and Miguel Hernández University (UMH) in Elche, has discovered that the developing brain can reorganize its sensory maps when the sense of touch is affected.
news-medical.net/news/20250306/Researchers-discover-brains-ability-to-reorganize-sensory-maps-after-loss-of-touch.aspx
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How tobacco and cannabis affect male fertility and genetic integrity
A study reveals cannabis and tobacco use harm sperm quality and DNA integrity, with cannabis causing greater damage, raising concerns for reproductive health.
news-medical.net/news/20250306/How-tobacco-and-cannabis-affect-male-fertility-and-genetic-integrity.aspx
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Study develops fused neural organoids with leptomeninges
A new study in the peer-reviewed journal Stem Cells and Development describes the development of a co-culture system of neural organoids generated from human induced pluripotent stem cells (iPSCs) fused with fetal leptomeninges from mice with fluorescently labeled meninges, called leptomeningeal neural organoid (LMNO) fusions.
news-medical.net/news/20250326/Study-develops-fused-neural-organoids-with-leptomeninges.aspx
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Novel global cooperative phenomena of cell interactions discovered in cervical cancer cells
A Japanese research team has discovered a novel global cooperative phenomena of cell interactions in cervical cancer cells. Their findings suggest that the cells are metabolically connected in a functional network.
news-medical.net/news/20250325/Novel-global-cooperative-phenomena-of-cell-interactions-discovered-in-cervical-cancer-cells.aspx
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Fatty acids in the blood may predict risk of developing schizophrenia from cannabis use
The UPV/EHU study, recently published in the journal Scientific Reports, has analyzed and compared the fatty acids in the blood of individuals with schizophrenia, of those with cannabis use disorder and of those with both diagnoses, with the aim of shedding light on new biomarkers and improving the understanding of the biological relationship between the two disorders.
news-medical.net/news/20250321/Fatty-acids-in-the-blood-may-predict-risk-of-developing-schizophrenia-from-cannabis-use.aspx
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Natural compounds identified as potential inhibitors of SARS-CoV-2 spike protein
The COVID-19 pandemic highlighted the urgent need for effective therapeutic agents against SARS-CoV-2.
news-medical.net/news/20250320/Natural-compounds-identified-as-potential-inhibitors-of-SARS-CoV-2-spike-protein.aspx
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Scientists discover irreversible peptide inhibitors for undruggable cancer target
For the first time scientists have identified promising drug candidates that bind irreversibly with a notoriously "undruggable" cancer protein target, permanently blocking it.
news-medical.net/news/20250320/Scientists-discover-irreversible-peptide-inhibitors-for-undruggable-cancer-target.aspx
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FDA-approved drug for chronic kidney disease may help mitigate antibiotic resistance
Increased antibiotic use can lead, seemingly paradoxically, to more problematic infections, as the bacteria evolve to resist the treatment.
news-medical.net/news/20250318/FDA-approved-drug-for-chronic-kidney-disease-may-help-mitigate-antibiotic-resistance.aspx
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In the Thymus We Trust: ProTcell Therapy & the Future of Allogeneic Immunotherapy
In this interview, News Medical speaks with Olivier Negre, Chief Scientific Officer at Smart Immune, about how immunotherapy is being revolutionized.
news-medical.net/news/20250318/In-the-Thymus-We-Trust-ProTcell-Therapy-the-Future-of-Allogeneic-Immunotherapy.aspx
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Understanding how JAK inhibitors may increase blood clot risk
Why do medications that are supposed to help patients with chronic inflammatory diseases sometimes lead to blood clots?
news-medical.net/news/20250317/Understanding-how-JAK-inhibitors-may-increase-blood-clot-risk.aspx
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Mitochondria may hold key to reducing inflammaging in aging cells
In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way.
news-medical.net/news/20250314/Mitochondria-may-hold-key-to-reducing-inflammaging-in-aging-cells.aspx
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Clinical trial tests herpes virus-based therapy for neurogenic bladder in people with spinal cord injury
A modified herpes virus that targets spinal cord nerve cells to treat neurogenic bladder in people with spinal cord injury is underway in a first-in-human clinical trial by UTHealth Houston at TIRR Memorial Hermann.
news-medical.net/news/20250312/Clinical-trial-tests-herpes-virus-based-therapy-for-neurogenic-bladder-in-people-with-spinal-cord-injury.aspx
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Scientists discover key molecular switch for blood stem cell regeneration
A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce new blood cells, according to a preclinical study led by Weill Cornell Medicine investigators.
news-medical.net/news/20250310/Scientists-discover-key-molecular-switch-for-blood-stem-cell-regeneration.aspx
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Research links kidney dysfunction to muscle weakness in myotonic dystrophy type 1
Thurman M. Wheeler, MD, of the Department of Neurology at Massachusetts General Hospital, is the senior author of a paper published in Nature Communications, "Analysis of human urinary extracellular vesicles reveals disordered renal metabolism in myotonic dystrophy type 1."
news-medical.net/news/20250308/Research-links-kidney-dysfunction-to-muscle-weakness-in-myotonic-dystrophy-type-1.aspx
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Study uncovers how transposons use telomeres for survival in bacteria
Transposons, or "jumping genes" – DNA segments that can move from one part of the genome to another – are key to bacterial evolution and the development of antibiotic resistance.
news-medical.net/news/20250307/Study-uncovers-how-transposons-use-telomeres-for-survival-in-bacteria.aspx
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Study reveals how silent X chromosome enhances female brain resilience
In a surprise, work in mice has found that the dormant X chromosome in females can reawaken late in life and turn on genes that keep the brain healthy.
news-medical.net/news/20250306/Study-reveals-how-silent-X-chromosome-enhances-female-brain-resilience.aspx
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TUM scientists develop new protein purification method using UV light
Proteins play a key role in the life sciences - from basic research and biotechnological applications to the development and manufacturing of pharmaceuticals.
news-medical.net/news/20250305/TUM-scientists-develop-new-protein-purification-method-using-UV-light.aspx
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