COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

19 June 2024 17:35

🎗 #افتخار جدید: کسب جایزه دکتر پرویزی (انجمن جراحان ارتوپدی ایران) توسط دکتر رامین شایان

♨️ بدین وسیله کسب جایزه دکتر پرویزی توسط جناب آقای دکتر رامین شایان، پژوهشگر محترم مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی، را به خانواده کوتار تبریک عرض می‌نماییم. این جایزه هر ساله از طرف انجمن جراحان ارتوپدی ایران به برترین پایان‌نامه رزیدنتی کشور تعلق می‌گیرد.

🌱 به امید حرکت به سمت هدف اصلی پژوهش‌ها.

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

14 June 2024 20:47

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Biomechanical Study of Using Patient-Specific Diaphyseal Femoral Cone in Revision Total Knee Arthroplasty (rTKA)

👥 Reza Nourishirazi, Ghazaleh Moradkhani, Arash SharafatVaziri, Hamidreza Nematy, Ramin Shayan-moghadam, Morad Karimpour

📔 Journal of Orthopaedics (Q3)

🗓 June 2024

🗂 Original research

📄 Abstract: The primary objective of revision total knee surgery is to achieve solid bone fixation. Generally, this could be accomplished using sleeves and long stems, which require substantial remaining bone stock and may increase the risk of stem tip pain. An alternative approach involves the use of customized diaphyseal cones, which can preserve the integrity of the bone canal. This study evaluates the impact of employing femoral diaphyseal cones with various stem lengths on stress distribution and relative motion. CT scan data from five patients were used to generate the 3D model of the femur, cement, customized stems, and cones, along with assigning patient-specific material for each candidate’s femur. Three different stem lengths, both with and without the customized cone, were assessed under three gait loading conditions to compare the resulting Von Mises stress distribution and relative motion. Analysis indicated that the use of customized femoral cones moderately increases stress distribution values up to 30 % while significantly reducing relative motion at the femoral canal-cone interface by nearly 60 %. The presence of the cone did not significantly alter relative motion with varying stem lengths, although stem length variation without a cone substantially affected these values. Incorporating cones alongside stems enhances metaphyseal fixation, reduces stress shielding, potentially allowing for the use of shorter stems. Furthermore, cones promote osseointegration by minimizing relative motion, ultimately improving prosthetic stability.

🔗 https://doi.org/10.1016/j.jor.2024.06.002

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

08 June 2024 05:19

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Postural Control Measures After Lateral Ankle Sprain While Wearing Ankle Orthoses: A Systematic Review

👥 Mahmood Bahramizadeh, Hanieh Khaliliyan*, Arash Sharafatvaziri, Ebrahim Sadeghi-Demneh, Lukasz Szarpak, Michal Pruc, Aanuoluwapo Adeyimika Afolabi, Francesco Chirico

📔 Iranian Rehabilitation Journal (Q4)

🗓 March 2024

🗂 Review

📄 Abstract: Ankle orthoses are one of the interventions used to prevent first and repeated lateral ankle sprains. We conducted this systematic review of the literature to investigate the effect of ankle orthoses on postural control in individuals with acute, chronic, or functional ankle sprains. Three electronic databases (Scopus, PubMed, and Web of Science) were searched for experimental studies using predefined keywords. We used the PRISMA method to select articles. Initially, the articles were examined for inclusion criteria and then assessed for their quality based on the physiotherapy evidence database scale. In the initial search, we retrieved 156 articles. After following the steps of the PRISMA flowchart and reviewing the entire text, only 14 reports met the inclusion criteria of this study. We extracted data from population, intervention, and outcome measures. Overall, ankle orthoses were effective in improving the static postural control of patients with lateral ankle sprains; however, the dynamic postural control results were unclear. Since most people who experience lateral ankle sprains have both functional and mechanical instability, ankle orthoses may affect both types of instability and thereby improve postural control.

🔗 http://dx.doi.org/10.32598/irj.22.1.1719.3

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

30 May 2024 09:43

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Comparative Study of External Fixators With Different Spatial Configurations in the Damage Control Surgery of Comminuted Diaphyseal Fracture

👥 Yousof Mohandes*, Mohammad Tahami, Amir R. Askari

📔 Iranian Journal of Science and Technology, Transactions of Mechanical Engineering (Q2)

🗓 May 2024

🗂 Original research

📄 Abstract: Fractures in the lower extremities are sometimes accompanied by severe damage, so definitive treatments with extensive surgical exposure are impractical. Extensive traumatization and swelling of surrounding tissue often dictate the use of external fixators as a temporary treatment for immediate stabilization of compound fractures. External fixation offers a variety of possible spatial configurations. Adequate fracture stabilization demands a good understanding of the stiffness, strength, sustainability, and tilting of external fixators of different frames. An improper frame can result in nonunion, malunion, delayed healing, and bone re-fracture, some of which are indications for revision surgery. This study employs a numerical approach to assess the stiffness, stress distribution, pin loosening, and interfragmentary displacement in different configurations of external fixators applied to a comminuted fracture in the diaphyseal region of the tibia. Unilateral fixators with single and double rods, bilateral, biplanar, and triangular frames with and without end cross-links are different configurations examined in-silico. Results show that the triangular frame with cross-links exhibits the stiffest, strongest, and most sustainable construct in axial, bending, and torsion modes. Except for the torsion mode, adding the end cross-links does little to increase the stiffness and strength of biplanar and triangular frames. Moreover, doubling the rod considerably improves construct stiffness and strength under axial compression load while appearing to be less superior in torsional stiffness and pin loosening. Furthermore, the bilateral frame demonstrates the most uniform displacement across the fracture gap. The results of this study could be used for preoperative planning of diaphyseal fracture management with external fixators.

🔗 https://doi.org/10.1007/s40997-024-00777-8

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

13 May 2024 18:49

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review

👥 Sepideh Yadegar, Fatemeh Mohammadi, Amirhossein Yadegar, Ali Mohammadi Naeini, Aryan Ayati, Nesa Milan, Amirhossein Tayebi, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani*

📔 Phytotherapy Research (Q1)

🗓 May 2024

🗂 Review

📄 Abstract: Resveratrol (RSV) has garnered significant attention in recent years due to its potential benefits against chronic diseases. However, its effects and safety in older adults have not been comprehensively studied. This study aimed to determine the effects and safety of RSV supplementation in older adults. MEDLINE/PubMed, Scopus, and Web of Science databases were comprehensively searched for eligible studies. Studies were enrolled if they were randomized clinical trials and had incorporated RSV supplementation for older adults. Two independent authors conducted the literature search, and eligibility was determined according to the PICOS framework. Study details, intervention specifics, and relevant outcomes were collected during the data collection. The Cochrane RoB-2 tool was used to evaluate the risk of bias. This review included 10 studies. The combination of RSV and exercise improved exercise adaptation and muscle function in healthy older adults and physical performance and mobility measures in individuals with functional limitations. RSV showed potential neuroprotective effects in patients with Alzheimer's disease. In overweight individuals, RSV demonstrated a positive impact on cognitive function, but it increased some biomarkers of cardiovascular disease risk at high doses. In older adults with diabetes and those with peripheral artery disease (PAD), RSV was not more effective than placebo. No study reported significant adverse events following RSV treatment. RSV can improve various health parameters in age-related health conditions. However, the optimal dosage, long-term effects, and potential interactions with medications still need to be investigated through well-designed RCTs.

🔗 http://dx.doi.org/10.1002/ptr.8171

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

01 May 2024 05:33

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Sleep profiles in epilepsy patients undergoing monotherapy and polytherapy: A comparative cross-sectional study

👥 Alireza Arvin, Morvarid Taebi, Zahra Khazaeipour, Arezu Najafi, Abbas Tafakhori, Sakineh Ranji-Bourachaloo, Hamed Amirifard*

📔 Epilepsy & Behavior (Q2)

🗓 April 2024

🗂 Original research

📄 Abstract: Sleep disturbances commonly reported among epilepsy patients have a reciprocal relationship with the condition; While epilepsy and anti-seizure medications (ASMs) can disrupt sleep structure, disturbed sleep can also exacerbate the frequency of seizures. This study explored subjective sleep disturbances and compared sleep profiles in patients who underwent ASM monotherapy and polytherapy. We enrolled 176 epilepsy patients who completed a structured questionnaire containing demographic and clinical information and the Persian versions of the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and Patient Health Questionnaire-9 (PHQ-9) to evaluate sleep quality, insomnia, excessive daytime sleepiness (EDS), and depressive symptoms, respectively. Chi-square and Mann-Whitney U tests were employed to analyze the association between variables, and logistic regression analysis was conducted to identify factors predicting sleep disturbances. Comparative analysis of mono/polytherapy groups revealed a significantly higher prevalence of insomnia and EDS among patients on polytherapy compared to monotherapy. However, no significant difference was found in sleep quality between the two groups. Logistic regression analysis revealed that a depressive mood serves as a robust predictor for sleep issues, whereas treatment type did not emerge as an independent predictor of sleep disturbances. Our findings suggest that an increased number of ASMs does not inherently result in a higher incidence of sleep issues. Therefore, multiple ASMs may be prescribed when necessary to achieve improved seizure control. Furthermore, this study underscores the importance of comprehensive management that addresses seizure control and treating affective symptoms in individuals with epilepsy.

🔗 https://doi.org/10.1016/j.yebeh.2024.109799

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

29 April 2024 05:03

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Challenges of Using C-Arm Fluoroscopy Systems: A Mixed Method Study Investigating Orthopedic Surgeons’ Experience

👥 Mobina Gharib, Shakiba Mohammadi*, Mohammadreza Mohammadi, Nastaran Maghbouli, Mohammad Hossein Nabian

📔 Journal of Iranian Medical Council (Q4)

🗓 March 2024

🗂 Original research

📄 Abstract: Intraoperative fluoroscopy systems are widely used nowadays, where their use allows a shorter duration of procedure time and better anatomical localization. The current study aims to investigate the most common challenges of C-arm fluoroscopy systems application. This mixed-method study was carried out in February and March 2022. After the literature review, a qualitative study was designed using semi-structured interviews to find important themes and subthemes required to design a web survey. The web survey was completed by the Persian Orthopedic Trauma Association (POTA) event’s international presenters. Nine orthopedic surgeons participated in interviews and 27 participants filled out the questionnaires. Five main themes including Physical Aspect, Mechanical Aspect, Software Options, Image Quality, and Radiation Exposure were extracted. Generally, over 80% of the web survey participants agreed that the size and shape of the base of C-arm fluoroscopy systems, C-arm diameter (space between tube and detector), and maneuvering and positioning of the C-arm fluoroscopy systems can interfere with surgical procedures. 100% of the participants agreed that providing two different views (e.g., AP and lateral) from the surgical site with one shot can be beneficial. The effectiveness of real-time visualization of radiation exposure on exposure rate was acknowledged by more than 92% of the participants. Although the C-arm fluoroscopy systems are widely used in surgical procedures, there are considerable issues regarding the application of this imaging modality in the operation room, and medical equipment companies should pay more attention to these issues to facilitate the use of these systems.

🔗 https://doi.org/10.18502/jimc.v7i2.15047

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

27 April 2024 09:12

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Intrathecal baclofen efficacy for managing motor function and spasticity severity in patients with cerebral palsy: a systematic review and meta-analysis

👥 Mahdi Masrour, Amir Zare, Ana Presedo*, Mohammad Hossein Nabian*

📔 BMC Neurology (Q2)

🗓 April 2024

🗂 Review

📄 Abstract: Spasticity can significantly affect a patient’s quality of life, caregiver satisfaction, and the financial burden on the healthcare system. Baclofen is one of only a few options for treating spasticity. The purpose of this study is to investigate the impact of intrathecal baclofen (ITB) therapy on severe spasticity and motor function in patients with cerebral palsy. We conducted a systematic review in PubMed, Scopus, Ovid, and the Cochrane Library in accordance with the PRISMA guidelines. We included studies based on eligibility criteria that included desired participants (cerebral palsy patients with spasticity), interventions (intrathecal baclofen), and outcomes (the Ashworth scales and the Gross Motor Function Measure [GMFM]). The within-group Cohen’s d standardized mean differences (SMD) were analyzed using the random effect model. We screened 768 papers and included 19 in the severity of spasticity section and 6 in the motor function section. The pre-intervention average spasticity score (SD) was 3.2 (0.78), and the post-intervention average score (SD) was 1.9 (0.72), showing a 40.25% reduction. The SMD for spasticity reduction was − 1.7000 (95% CI [-2.1546; -1.2454], p-value < 0.0001), involving 343 patients with a weighted average age of 15.78 years and a weighted average baclofen dose of 289 µg/day. The SMD for the MAS and Ashworth Scale subgroups were − 1.7845 (95% CI [-2.8704; -0.6986]) and − 1.4837 (95% CI [-1.8585; -1.1088]), respectively. We found no relationship between the participants’ mean age, baclofen dose, measurement time, and the results. The pre-intervention average GMFM (SD) was 40.03 (26.01), and the post-intervention average score (SD) was 43.88 (26.18), showing a 9.62% increase. The SMD for motor function using GMFM was 0.1503 (95% CI [0.0784; 0.2223], p-value = 0.0030), involving 117 patients with a weighted average age of 13.63 and a weighted average baclofen dose of 203 µg/day. In 501 ITB implantations, 203 medical complications were reported, including six new-onset seizures (2.96% of medical complications), seven increased seizure frequency (3.45%), 33 infections (16.26%), eight meningitis (3.94%), and 16 cerebrospinal fluid leaks (7.88%). Delivery system complications, including 75 catheter and pump complications, were also reported. Despite the risk of complications, ITB has a significant impact on the reduction of spasticity. A small but statistically significant improvement in motor function was also noted in a group of patients.

🔗 https://doi.org/10.1186/s12883-024-03647-7

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

15 March 2024 02:26

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Hypermobile lateral meniscus: A systematic review of current treatment options

👥 Fardis Vosoughi, Asma Mafhoumi, Mahdi Gouravani, Robert F LaPrade, Arash Sherafat Vaziri, Mohammad Movahedinia, Sohrab Keyhani*

📔 Knee Surgery, Sports Traumatology, Arthroscopy (Q1)

🗓 March 2024

🗂 Review

📄 Abstract: The reliable data on the incidence of hypermobile lateral meniscus (HLM) and its clinical manifestations, diagnostic methods and therapeutic approaches are limited. This systematic study aimed to review available treatment options for HLM and the outcomes of each approach. A systematic search was performed in four electronic databases (PubMed, EMBASE, Scopus, Web of Science) to identify studies in which arthroscopically confirmed cases of HLM were treated surgically or nonsurgically, and the required data comprising study characteristics, patient data, treatment approaches and outcome measures were extracted from eligible studies. Twenty studies with a total of 212 patients (138 males and 74 females) and 219 knees were included. The most frequently reported symptoms were locking sensations, knee pain, giving way and snapping. Treatments used by the studies were: radiofrequency energy in two studies; arthroscopic partial meniscectomy in one study; open surgery in two studies; and arthroscopic meniscal repair in 17 studies. Eleven studies used an all-inside repair method and an inside-out meniscal repair was reported in eight studies. Three studies reported the usage of posterior arthroscopy for therapeutic or diagnostic approaches. Evaluation of symptom resolution was the main outcome measurement for which almost all of the studies stated relief of symptoms after intervention. Despite the lack of definite consensus about the most appropriate intervention for HLM, therapeutic preference was directed towards arthroscopic all-inside and inside-out repair techniques. Although the surgeon's decision remains the key factor in choosing the most suitable treatment option for each individual, posterior arthroscopic meniscal repair may be considered as a better option for HLM treatment according to the findings of this review.

🔗 https://doi.org/10.1002/ksa.12102

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

08 March 2024 07:48

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Distal femoral osteotomy and patellar tendon advancement for the treatment of crouch gait in patients with bilateral spastic cerebral palsy

👥 Mohammad Hossein Nabian, Shayan Abdollah Zadegan, Cindy Mallet, Yamile Neder, Brice Ilharreborde, Anne Laure Simon, Ana Presedo*

📔 Gait & Posture (Q1)

🗓 March 2024

🗂 Original research

📄 Abstract: Crouch gait, or flexed knee gait, represents a common gait pattern in patients with spastic bilateral cerebral palsy (CP). Distal femoral extension and/or shortening osteotomy (DFEO/DFSO) and patellar tendon advancement (PTA) can be considered as viable options when knee flexion contractures are involved. Better outcomes have been reported after a combination of both, independently of the presence of knee extensor lag. In this study, we evaluated the clinical and kinematic outcomes of these procedures. We reviewed a cohort of 52 limbs (28 patients) who were treated for crouch gait by DFEO/DFSO alone (group 1, n = 15) or DFEO/DFSO + PTA (group 2, n = 37) as a part of single event multilevel surgery (SEMLS). The mean age at surgery was 14 years, and the mean follow-up time was 18 months. The physical examination data and three-dimensional standardized gait analysis were collected and analyzed before the surgery and postoperatively. Overall knee range of motion improved in all limbs. The knee flexion decreased significantly in both groups at initial, mid, and terminal stance. Hip flexion significantly decreased in mid-stance for limbs in group 2. Both clinical and gait parameters were most improved in limbs who underwent DFEO/DFSO + PTA. Increased pelvic tilt was observed in both groups after surgery. Although DFEO/DFSO alone was successful in correcting knee flexion contractures, PTA has helped to improve knee extensor lag and knee extension during gait.

🔗 https://doi.org/10.1016/j.gaitpost.2024.02.019

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

04 February 2024 13:47

✳️ کارگاه مبانی مقاله‌نویسی در علوم پزشکی

✏️ با تدریس دکتر شاهین آخوندزاده، استاد دانشگاه علوم پزشکی تهران و پژوهشگر ۱٪ پر استناد برتر دنیا

🗓 پنج‌شنبه ۲۶ بهمن و ۱۷ اسفند ۱۴۰۲، ساعت ۸ الی ۱۲ صبح

👥 به صورت هیبرید (حضوری + مجازی)

🏛 محل برگزاری: بیمارستان شریعتی

📄 همراه با ارائه گواهی‌نامه حضور در کارگاه

❇️ فیلم جلسات برگزار شده به صورت ضبط‌شده در اختیار ثبت‌نام‌کنندگان قرار می‌گیرد.

♨️ کد تخفیف ۳۰ درصدی:
cotar_tums

🔻 ثبت‌نام و اطلاعات بیشتر:
cotar.tums.ac.ir/sww

🆔 @Orthopedic_Association
🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

04 January 2024 05:15

🎗 #افتخار جدید: مرکز برگزیده در آیین تجلیل از پژوهشگران، فناوران و واحد‌های برگزیده دانشگاه

♨️ بدین وسیله برگزیده شدن مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی برای حیطه اثرات فراآکادمیک در آئین تجلیل از پژوهشگران، فناوران و واحد‌های برگزیده دانشگاه علوم پزشکی تهران که در تاریخ ۱۳ دی ماه ۱۴۰۲ در تالار دارالفنون ساختمان ستاد مرکزی برگزار شد، را به خانواده پرتلاش کوتار تبریک عرض می‌نماییم.

🌱 به امید حرکت به سمت هدف اصلی پژوهش‌ها.

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

28 December 2023 11:59

✳️ مجموعه وبینار آموزش برخورد با بیماران مالتیپل تروما (ATLS)

✏️ با تدریس دکتر محمد افضلی‌مقدم
▫️عضو هیئت علمی دانشگاه علوم پزشکی تهران
▫️رئیس بخش اورژانس مجتمع بیمارستانی امام خمینی (ره)

📚 بر اساس کتاب
Rosen’s Emergency medicine 2023

🗓 دوشنبه ها، ساعت ۲۱، به مدت ۴ الی ۵ هفته (۴ یا ۵ جلسه)، به صورت مجازی در اسکای‌روم

🔗 لینک ثبت‌نام در دوره

❓ پرسش‌وپاسخ: @ORA_admin1

🆔 @Orthopedic_Association
🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

25 December 2023 18:35

🎗 #افتخار جدید: انتخاب دکتر نبیان به عنوان استاد برگزیده

♨️ بدین وسیله انتخاب جناب آقای دکتر محمدحسین نبیان، ریاست محترم مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی، به عنوان استاد منتخب نوزدهمین دوره نکوداشت مقام استاد در دانشگاه علوم پزشکی تهران که به پیشنهاد و انتخاب دانشجویان و دانشگاهیان بوده، را به خانواده کوتار تبریک عرض می‌نماییم.

🌱 به امید حرکت به سمت هدف اصلی پژوهش‌ها.

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

06 December 2023 05:40

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Medical education during the COVID-19 pandemic: lessons for the orthopedic departments

👥 Zahra Vahdati, Hossein Nematian, Amir Reza Farhoud, Mohammad Naghi Tahmasebi, Shahram Rahimi-Dehgolan, Seyed Mohammad Javad Mortazavi, Reza Shahryar Kamrani, Leila Oryadi Zanjani, Mohammad Reza Golbakhsh, Roya Nasl Seraj, Mohammad Hossein Nabian*

📔 BMC Medical Education (Q1)

🗓 June 2023

🗂 Original research

📄 Abstract: After the Coronavirus pandemic, many educational routines were stopped for the safety of medical staff. To achieve educational goals, we have implemented new policies in our hospitals. In this study, we aimed to evaluate the effect of such strategies. This survey-based study uses questionnaires to assess newly implemented educational strategies. We surveyed 107 medical staff of the orthopedic department of Tehran University of Medical Sciences, including faculty members, residents, and students. The survey contained three series of questionnaires for these groups. The maximum satisfaction for all three groups was observed in the platform and facilities for using e-classes, and the cost- and time-saving capabilities (Respectively, faculty members (FM): 81.8%, residents (R): 95.2%, students/interns (S/I): 87.0%; FM: 90.9%, R: 88.1%, S/I: 81.5%). The new policies have been shown to reduce the stress level of most trainees, increase the quality of knowledge-based education, increase the opportunity for reexamining educational content, expand discussion and research opportunities, and improve work conditions. There was a broad acceptance of the virtual journal clubs and morning reports. However, there were discrepancies between residents and faculty members on issues such as the evaluation of trainees, the new educational curriculum, and flexible shift schedules. Our strategies failed to improve skill-based education and patient treatment status. Most participants indicated that e-learning should be used with face-to-face training post-pandemic (FM: 81.8%, R: 83.3%, S/I: 75.9%). Our efforts to optimize the educational system during this crisis have generally improved trainees’ work conditions and educational experience. Most participants believed that e-learning and virtual methods should be used alongside traditional training as a complementary component after the pandemic.

🔗 https://doi.org/10.1186/s12909-023-04388-w

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

15 June 2024 17:54

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Proximal femoral varus osteotomy for Legg–Calvé–Perthes disease: Do age and lateral pillar classifications influence short-to-mid-term clinical and radiological outcomes?

👥 Nima Hoseini-Zare, Peyman Mirghaderi, Brice Ilharreborde, Kiarash Roustai-Geraylow, Alireza Moharrami, Taghi Baghdadi, Seyed Hadi Kalantar, Mohammad Hossein Nabian

📔 Orthopaedics & Traumatology: Surgery & Research (Q1)

🗓 May 2024

🗂 Original research

📄 Abstract: Proximal femoral varus osteotomy (FVO) is one of the most used treatment methods with acceptable outcomes for Legg–Calvé–Perthes disease (LCPD). We aimed to investigate the influence of age at disease onset and the Lateral Pillar classification on clinical and radiological outcomes of FVO surgery LCPD patients between 6–12 years of age. Proximal FVO surgery in the early fragmentation phase of LCPD patients led to acceptable clinical and radiographic outcomes in a 3-year follow-up, regardless of preoperative age and Herring type. Fifty patients with LCPD (Herring groups B, B/C, and C) who underwent FVO were retrospectively reviewed. We evaluated radiological [center-edge angle, extrusion index, epiphyseal index, acetabular index, articulo-trochanteric distance (ATD)] and clinical [hip abduction range of motion (ROM), Trendelenburg sign, pain, and Harris hip score (HHS)] outcomes with a follow-up of 37.3 ± 10.5 months (range: 24–180 months). Finally, the overall treatment outcome was assessed using the Stulberg classification. The ROC curve analysis did not reveal any significant relationship between age and clinical or radiological outcomes, and there was no predictable age cut-off for surgical outcomes (p = 0.13). No significant difference was found in Stulberg classification at the follow-up between patients with type B, B/C, and C of the lateral pillar (p > 0.05). Our results demonstrated that open-wedge proximal FVO surgery in the early fragmentation phase of LCPD patients led to acceptable clinical and radiographic outcomes in a 3-year follow-up. Each sample of our study was very small and a lot of variables were measured, making this result not adequately strong enough to draw a robust conclusion. However, FVO surgery remains a possible suggestion for patients in the early fragmentation phase, and age and lateral pillar type may not be limiting factors.

🔗 https://doi.org/10.1016/j.otsr.2024.103909

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

12 June 2024 07:21

📣 کارگاه مبانی مقاله‌نویسی در علوم پزشکی

🔄 جلسه سوم (هدیه): چگونه یک مقاله را اصلاح و داوری کنیم؟

👨‍🏫 با تدریس دکتر شاهین آخوندزاده، استاد دانشگاه علوم پزشکی تهران و پژوهشگر ۱٪ پر استناد برتر دنیا

📆 پنج‌شنبه، ۲۴ خرداد ماه

⏰ ساعت ۸ الی ۱۲

🌐 به صورت مجازی در بستر اسکای‌روم

© همراه با ارائه گواهی‌نامه حضور در کارگاه

🔖 فیلم جلسات برگزار شده به صورت ضبط‌شده در اختیار ثبت‌نام‌کنندگان قرار می‌گیرد.

♨️ کد تخفیف ۳۰ درصدی:
cotar_tums

🔽 ثبت‌نام و اطلاعات بیشتر:
cotar.tums.ac.ir/sww

🆔 @Orthopedic_Association
🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

06 June 2024 09:24

📣 کارگاه مبانی مقاله‌نویسی در علوم پزشکی

🔄 جلسه سوم (هدیه): چگونه یک مقاله را اصلاح و داوری کنیم؟

👨‍🏫 با تدریس دکتر شاهین آخوندزاده، استاد دانشگاه علوم پزشکی تهران و پژوهشگر ۱٪ پر استناد برتر دنیا

📆 پنج‌شنبه، ۲۴ خرداد ماه

⏰ ساعت ۸ الی ۱۲

🌐 به صورت مجازی در بستر اسکای‌روم

© همراه با ارائه گواهی‌نامه حضور در کارگاه

🔖 فیلم جلسات برگزار شده به صورت ضبط‌شده در اختیار ثبت‌نام‌کنندگان قرار می‌گیرد.

♨️ کد تخفیف ۳۰ درصدی:
cotar_tums

🔽 ثبت‌نام و اطلاعات بیشتر:
cotar.tums.ac.ir/sww

🆔 @Orthopedic_Association
🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

25 May 2024 04:45

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Hypertrophic synovial plica in the lateral side of the knee - A case report: Case report and literature review

👥 Arash Sherafatvaziri, Fardis Vosoughi, Alireza Mirzamohamadi, Erfan Babaei Nejad, Ramin Shayan-Moghadam*

📔 International Journal of Surgery Case Reports (Q3)

🗓 June 2024

🗂 Case report

📄 Abstract: Plicae or synovial folds can be detected in different joints, especially around the knee. Synovial plicae pathologies are rare conditions with difficulty in diagnosis because of various symptoms overlapping with other diseases. We reported a rare case of symptomatic hypertrophic synovial plica in the lateral side of the knee in a 12-year-old boy following a traumatic event almost two years before the surgery. The diagnosis and treatment were conducted by knee arthroscopy, and follow-up of the patients showed significant improvements with no pain or range of motion restrictions. The reported case had a significantly lower age of presentations compared to most previously reported cases, and he was diagnosed with lateral knee hypertrophic plicae, while medial knee hypertrophic plicae are more commonly reported, which is considered rare findings. Contrary to previous studies of lateral plica, our case had a history of significant direct trauma, and he was not a professional athlete. Furthermore, based on evidence, hypertrophic synovial plicae are mostly asymptomatic, but in our case, there was a pain in his knee that worsened in flexion. Physicians should consider the possibility of synovial hypertrophic plicae, especially in younger patients with histories of direct traumatic events.

🔗 https://doi.org/10.1016/j.ijscr.2024.109705

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🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

04 May 2024 09:42

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Genetic and Lifestyle Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Relationship with Premature Coronary Artery Disease: A Study on the Pars Cohort

👥 Amir Anushiravani, Maryam Rayatpisheh, Amir Kasaeian*, Iman Menbari Oskouie*

📔 Archives of Iranian Medicine (Q1)

🗓 May 2024

🗂 Original research

📄 Abstract: The main objective of this study is to identify the risk factors of metabolic dysfunction-associated fatty liver disease (MAFLD) in coronary artery disease (CAD) patients. The present retrospective cohort study is part of the Pars Cohort Study (PCS). The participants were categorized as having MAFLD or not. The pattern of independent variables in patients was compared with those who did not have MAFLD. All variables were retained in the multivariable logistic regression model. Totally, 1862 participants with CAD were enrolled in this study. MAFLD was diagnosed in 647 (40.1%) participants. Gender, diabetes, hypertension, tobacco, opium, alcohol, age, weight, waist circumference, cholesterol, HDL, triglyceride, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly different in MAFLD and non-MAFLD patients. Also, the results of multivariable logistic regression show male gender (OR=0.651, 95% CI: 0.470‒0.902, P value=0.01) and opium consumption (OR=0.563, 95% CI: 0.328‒0.968, P value<0.001) to be negative risk factors of MAFLD occurrence in CAD patients. Having diabetes (OR=2.414, 95% CI: 1.740-3.349, P value<0.001), high waist circumference (OR=1.078, 95% CI: 1.055‒1.102, P value<0.01), high triglyceride (OR=1.005, 95% CI: 1.001‒1.008, P value=0.006), and high ALT (OR=1.039, 95% CI: 1.026‒1.051, P value<0.01) were positive risk factors of MAFLD in CAD patients. Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.

🔗 https://doi.org/10.34172/aim.2024.36

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COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

30 April 2024 05:35

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Machine Learning for prediction of violent behaviors in schizophrenia spectrum disorders: a systematic review

👥 Mohammadamin Parsaei, Alireza Arvin, Morvarid Taebi, Homa Seyedmirzaei, Giulia Cattarinussi, Fabio Sambataro, Alessandro Pigoni, Paolo Brambilla, Giuseppe Delvecchio*

📔 Frontiers in Psychiatry (Q2)

🗓 March 2024

🗂 Review

📄 Abstract: Schizophrenia spectrum disorders (SSD) can be associated with an increased risk of violent behavior (VB), which can harm patients, others, and properties. Prediction of VB could help reduce the SSD burden on patients and healthcare systems. Some recent studies have used machine learning (ML) algorithms to identify SSD patients at risk of VB. In this article, we aimed to review studies that used ML to predict VB in SSD patients and discuss the most successful ML methods and predictors of VB. We performed a systematic search in PubMed, Web of Sciences, Embase, and PsycINFO on September 30, 2023, to identify studies on the application of ML in predicting VB in SSD patients. We included 18 studies with data from 11,733 patients diagnosed with SSD. Different ML models demonstrated mixed performance with an area under the receiver operating characteristic curve of 0.56-0.95 and an accuracy of 50.27-90.67% in predicting violence among SSD patients. Our comparative analysis demonstrated a superior performance for the gradient boosting model, compared to other ML models in predicting VB among SSD patients. Various sociodemographic, clinical, metabolic, and neuroimaging features were associated with VB, with age and olanzapine equivalent dose at the time of discharge being the most frequently identified factors. ML models demonstrated varied VB prediction performance in SSD patients, with gradient boosting outperforming. Further research is warranted for clinical applications of ML methods in this field.

🔗 https://doi.org/10.3389/fpsyt.2024.1384828

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🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

28 April 2024 09:18

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Sex Dimorphism in Pain Threshold and Neuroinflammatory Response: The Protective Effect of Female Sexual Hormones on Behavior and Seizures in an Allergic Rhinitis Model

👥 Mohammad Elahi, Zahra Ebrahim Soltani, Arya Afrooghe, Elham Ahmadi, Ahmad Reza Dehpour

📔 Journal of Neuroimmune Pharmacology (Q1)

🗓 April 2024

🗂 Review

📄 Abstract: Our previous research demonstrated that allergic rhinitis could impact behavior and seizure threshold in male mice. However, due to the complex hormonal cycles and hormonal influences on behavior in female mice, male mice are more commonly used for behavioral tests. In this study, we aimed to determine whether these findings were replicable in female mice and to explore the potential involvement of sexual hormones in regulating neuroinflammation in an allergic model. Our results indicate that pain threshold was decreased in female mice with allergic rhinitis and the levels of IL-23/IL-17A/IL-17R were increased in their Dorsal root ganglia. However, unlike males, female mice with AR did not display neuropsychological symptoms such as learning and memory deficits, depression, and anxiety-like behavior. This was along with decreased levels of DNA methyl transferase 1 (DNMT1) and inflammatory cytokines in their hippocampus. Ovariectomized mice were used to mitigate hormonal effects, and the results showed that they had behavioral changes and neuroinflammation in their hippocampus similar to male mice, as well as increased levels of DNMT1. These findings demonstrate sex differences in how allergic rhinitis affects behavior, pain sensitivity, and seizure thresholds. Furthermore, our data suggest that DNMT1 may be influenced by sexual hormones, which could play a role in modulating inflammation in allergic conditions.

🔗 https://doi.org/10.1007/s11481-024-10114-0

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🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

09 April 2024 00:24

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Gait and muscle activity measures after biomechanical device therapy in subjects with ankle instability: A systematic review

👥 Hanieh Khaliliyan, Arash Sharafatvaziri, Zahra Safaeepour, Mahmood Bahramizadeh*

📔 Foot (Q2)

🗓 March 2024

🗂 Review

📄 Abstract: Health specialists suggest a conservative approach comprising non-pharmacological interventions as the initial course of action for individuals with repetitive ankle sprain due to ankle instability. This systematic review aimed to assess the effectiveness of biomechanical devices (Foot Orthoses, Ankle Orthoses, and Taping) on gait and muscle activity in individuals with ankle instability. A systematic search was performed on electronic databases, including PubMed, EMBASE, Clinical Trials.gov, Web of Science, and Scopus. The PEDro scoring system was used to evaluate the quality of the included studies. We extracted data from population, intervention, and outcome measures. In the initial search, we found 247 articles. After following the steps of the PRISMA flowchart, only 22 reports met the inclusion criteria of this study. The results show that biomechanical device therapy may increase swing time, stance time, and step. Additionally, studies suggest that these devices can reduce plantar flexion, inversion, and motion variability during gait. Biomechanical devices have the potential to optimize the subtalar valgus moment, push-off, and braking forces exerted during walking, as well as enhance the activity of specific muscles including the peroneus longus, peroneus brevis, tibialis anterior, gluteus medius, lateral gastrocnemius, rectus femoris, and soleus. Biomechanical devices affect gait (spatiotemporal, kinetic, and kinematic variables) and lower limb muscle activity (root mean square, reaction time, amplitude, reflex, and wave) in subjects with ankle instability.

🔗 https://doi.org/10.1016/j.foot.2024.102083

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🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

10 March 2024 15:05

✳️ فراخوان شورای اجرایی ۱۴۰۳

🔸 دو عنصر اساسی در ساختار مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی (COTAR) وجود دارد: کمیته‌هایی که از اعضای هیئت علمی تشکیل شده‌اند و به شورای پژوهشی معروف هستند و شورای اجرایی که از پژوهشگران ارشد و رئیس مرکز تشکیل شده‌اند. تمامی موفقیت‌ها و پیشرفت‌هایی که مرکز تاکنون داشته است، نتیجه‌ی تلاش‌ها و حضور مداوم این دو رکن بوده است.

🔹 اکنون با آغاز سال جدید، قرار است شورای اجرایی نیز اعضای جدید خود را بشناسد. به همین منظور، از تمامی دانشجویان و فارغ‌التحصیلان کوتاری دغدغه‌مند دعوت می‌شود تا با ثبت‌نام از طریق فرم زیر، آمادگی خود را جهت عضویت در این شورا اعلام نمایند:
🔗 https://forms.formool.ir/6hl69

❓ جهت اطلاع از سازوکار، نقش‌ها و وظایف اعضای شورای اجرایی، لطفا سند زیر را مطالعه نمایید:
https://cotar.tums.ac.ir/InfrastructureDoc

⏰ مهلت ثبت‌نام: سه شنبه ۲۹ اسفند ۱۴۰۲، ساعت ۲۳:۵۹

🌱 امید است که با تداوم این چرخه، پرقدرت به مسیر ادامه دهیم.

🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

15 February 2024 22:44

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Non-coding RNAs as potential therapeutic targets for receptor tyrosine kinase signaling in solid tumors: current status and future directions

👥 Aysan Moeinafshar, Mohammad Nouri, Nima Shokrollahi, Mahdi Masrour, Amirmohammad Behnam, Sahand Tehrani Fateh, Hossein Sadeghi, Mohammad Miryounesi & Mohammad-Reza

📔 Cancer Cell International (Q1)

🗓 January 2024

🗂 Review

📄 Abstract: This review article presents an in-depth analysis of the current state of research on receptor tyrosine kinase regulatory non-coding RNAs (RTK-RNAs) in solid tumors. RTK-RNAs belong to a class of non-coding RNAs (nc-RNAs) responsible for regulating the expression and activity of receptor tyrosine kinases (RTKs), which play a critical role in cancer development and progression. The article explores the molecular mechanisms through which RTK-RNAs modulate RTK signaling pathways and highlights recent advancements in the field. This include the identification of potential new RTK-RNAs and development of therapeutic strategies targeting RTK-RNAs. While the review discusses promising results from a variety of studies, encompassing in vitro, in vivo, and clinical investigations, it is important to acknowledge the challenges and limitations associated with targeting RTK-RNAs for therapeutic applications. Further studies involving various cancer cell lines, animal models, and ultimately, patients are necessary to validate the efficacy of targeting RTK-RNAs. The specificity of ncRNAs in targeting cellular pathways grants them tremendous potential, but careful consideration is required to minimize off-target effects, the article additionally discusses the potential clinical applications of RTK-RNAs as biomarkers for cancer diagnosis, prognosis, and treatment. In essence, by providing a comprehensive overview of the current understanding of RTK-RNAs in solid tumors, this review emphasizes their potential as therapeutic targets for cancer while acknowledging the associated challenges and limitations.

🔗 https://doi.org/10.1186/s12935-023-03203-2

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🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

05 January 2024 13:01

📷 برگزاری بخش عملی کارگاه کشت سلول آزمایشگاهی

🗓 ۱۳ دی ماه ۱۴۰۲
🏛 ساختمان مرکز تحقیقات شفا

🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

03 January 2024 14:25

❇️ انتشار #مقاله جدید با وابستگی کوتار توسط انتشارات Nature

💠 Cadaveric biomechanical assessment of different configurations for a novel pin and plate fixation method in distal humerus fractures

👥 Kaveh Same, Alireza Hakiminejad, Amir Nourani, Mohammad Hossein Nabian, Mehdi Foruozesh, Reza Shahriar Kamrani*

📔 Scientific Reports (Q1)

🗓 January 2024

🗂 Original Research

📄 Abstract: Use of dual pre-contoured plates has been accepted as the treatment of choice in distal humerus fractures despite challenges especially in very distal or highly fragmented fractures. Aiming to improve results in such instances, our newly proposed method uses several K-wires fixated by a small reconstruction plate. Drawing on the results of previous finite element studies, the current study aims to compare the stiffness of three clinically common variations of this method using biomechanical testing in cadaveric humeri. 24 samples were divided into three groups and fractures were simulated. Groups I and II used 1.5 mm K-wires in differing configurations while 2 mm wires were used in group III. All samples underwent compression, anterior and posterior bending, and torsional testing as well as failure testing. Our results indicated that Group III had significantly higher stiffness in flexion, extension, and torsion (p < 0.05). In failure, group III had the highest mean stiffness in anterior bending and torsion (861.2 N, 30.9 Nm). Based on previous and current results, this new Persian fixation method, especially when implemented using 2 mm K-wires, shows promise in achieving suitable stability and may be useful as an alternative approach in complex distal humerus fractures.

🔗 https://doi.org/10.1038/s41598-023-50976-7

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🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

27 December 2023 08:27

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 An additively manufactured titanium tilting suture anchor: a biomechanical assessment on human and ovine bone specimens

👥 Ali Abedi, Farzad Pourghazi, Maysa Eslami, Mohammad Hossein Nabian, Ali Mohammad Ali Mohammadi, Leila Oryadi Zanjani, Farzam Farahmand*

📔 Frontiers in Surgery (Q3)

🗓 November 2023

🗂 Original Research

📄 Abstract: A novel titanium tilting suture anchor was designed and fabricated using additive manufacturing. The anchor enjoyed a nonsymmetrical structure to facilitate its insertion procedure through a weight-induced tilt, a saw-teeth penetrating edge to provide a strong initial fixation into cancellous bones of various densities, and an appropriate surface texture to enhance the longterm fixation strength through bone ingrowth. Biomechanical tests were performed on 10 ovine and 10 human cadaveric humeri to examine the insertion procedure and assess the initial fixation strength of the anchor, in comparison with a standard screw-type anchor as control. This study indicated a simple yet reliable insertion procedure for the tilting anchor. All anchors survived after 400 cycles of cyclic loadings and failed in the load-to-failure step. There were no significant differences between the displacements and fixation stiffnesses of the anchors in either group. The ultimate failure load was significantly smaller (p<0.05) for tilting anchors in ovine group (273.7 ± 129.72 N vs. 375.6 ± 106.36 N), but not different in human group (311.8 ± 82.55 N vs. 281.9 ± 88.35). Also, a larger number of tilting anchors were pulled out in ovine group (6 vs. 3) but a smaller number in human group (4 vs. 6). It was concluded that the biomechanical performance of the designed tilting anchor is comparable with that of the standard screw-type anchors.

🔗 https://doi.org/10.3389/fsurg.2023.1195728

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🆔 @COTAR_TUMS

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

22 December 2023 23:28

🎗 #افتخار جدید: مقام شایسته تقدیر در هفتمین دوره ایده‌های برتر دانشجویی

♨️ کسب مقام «شایسته تقدیر» توسط آقای علی کاظمی، پژوهشگر ارشد مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی، بابت طرح پژوهشی با عنوان «بازسازی سه‌بعدی سطح مفصلی پلاتو تیبیا (مفصل زانو) از تصاویر X-ray دو بعدی با استفاده از شبکه‌های یادگیری عمیق به منظور افزایش دقت در جراحی‌های شکستگی پروگزیمال تیبیا» در هفتمین دوره جشنواره پژوهشی دانشجویان تحصیلات تکمیلی که در تاریخ ۱۹ و ۲۰ آذر ۱۴۰۲ در تالار ابن سینای دانشکده پزشکی برگزار شد، را به خانواده کوتار تبریک عرض می‌نماییم.

🌱 به امید حرکت به سمت هدف اصلی پژوهش‌ها.

COTAR | مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی

03 December 2023 17:09

❇️ انتشار #مقاله جدید با وابستگی کوتار

💠 Understanding the management of pediatric spondylodiscitis based on existing literature; a systematic review

👥 Narges Lashkarbolouk, Mahdi Mazandarani, Brice Ilharreborde, Mohammad Hossein Nabian*

📔 BMC Pediatrics (Q1)

🗓 December 2023

🗂 Review

📄 Abstract: Spondylodiscitis (SD), a rare disease in children, poses diagnostic challenges due to non-specific presenting symptoms, scarcity in incidence, and difficulty expressing pain in non-verbal children. A comprehensive search was conducted on three databases, including PubMed/Medline, Web of Science, and Scopus until March 2023. The inclusion criteria were studies that investigated the clinical characteristics, treatment, and complications of children's spondylodiscitis. Full text of cross-sectional and cohort studies were added. The quality assessment of cohort studies was conducted using the Newcastle-Ottawa Quality Assessment Scale. The search, screening, and data extraction were performed by two researchers independently. Clinical manifestations of discitis in children are nonspecific, such as back pain, fever, reduced ability or inability to walk or sit, limping, and reduced range of movements. The mean delay in the time of diagnosis was 4.8 weeks. The most affected site of all the studies was the lumbar spine. 94% of studies reported increased inflammatory markers such as white blood cell count, C-reactive protein, and erythrocyte sedimentation rate. Less than 30% of patients had positive blood cultures and biopsy findings. The most common microbiological results (64%) were Staphylococcus Aureus and Kingella kingae. In radiographic evaluation, intervertebral disk narrowing, lumbar lordosis reduction, loss of disk height, and destruction of the vertebral body have been reported. In all studies, antibiotic therapy was initiated; in 52% immobilization was employed, and 29% of studies reported surgery was performed, and the follow-up period differed from 1.5 months to 156 months. 94% of studies reported complications such as vertebral body destruction, back pain, kyphosis, reduced range of movement, scoliosis, and neurological complications. Spondylodiscitis is an uncommon, heterogeneous, multifactorial disease with resulting difficult and delayed diagnosis. Due to its morbidity, it is essential to investigate children with refusal to walk, gait disturbances, or back pain, particularly when associated with elevated inflammatory markers.

🔗 https://doi.org/10.1186/s12887-023-04395-2

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